Fluorine compounds are known for their abundance in more than 20% of pharmaceutical
and agrochemical products mainly due to the enhanced lipophilicity, metabolic stability and …

The difunctionalizative trifluoromethylation of unsaturated C− C bonds is a highly useful and
efficient method for the synthesis of trifluoromethyl compounds with attractive architectures …

Benzoxazines are important structures in pharmaceuticals and functional molecules. We
herein describe an electrochemical oxidative strategy for the synthesis of benzoxazines …

Generally, oxy-trifluoromethylation in olefins is achieved using oxidants and transition metal
catalysts. However, labile olefins remain unexplored due to their incompatibility with harsh …

Heterocycles containing N and O are important structures in pharmaceuticals,
agrochemicals and functional molecules. The synthesis of these compounds usually …

The visible-light-mediated oxydifluoromethylation of olefinic amides with difluoromethyl
sulfones has been explored. This method allows for an efficient and practical synthesis of a …

Synthesis technologies can be used directly and selectively to construct two different
heterocycles from one substrate. Herein, we introduce a mild and efficient electrochemical …

A simple and efficient tert-butyl hydroperoxide-mediated direct trifluoromethylation of
indazoles using sodium trifluoromethanesulfinate has been developed under metal-free …

Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful
building blocks. In this sequence, we have developed a visible-light-promoted regioselective …

Herein, we reported the first copper-catalyzed highly efficient C (sp2)–H functionalization of
unprotected naphthols and phenols with α-aryl-α-diazoesters. In this transformation, CuCl2 …