Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?
CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …
as the leading cause of death, contributing to a significant and growing global health and …
Developmental Toxicity Studies: The Path towards Humanized 3D Stem Cell-Based Models
MA Branco, TC Nunes, JMS Cabral… - International Journal of …, 2023 - mdpi.com
Today, it is recognized that medicines will eventually be needed during pregnancy to help
prevent to, ameliorate or treat an illness, either due to gestation-related medical conditions …
prevent to, ameliorate or treat an illness, either due to gestation-related medical conditions …
Predictive biomarkers for embryotoxicity: a machine learning approach to mitigating multicollinearity in RNA-Seq
Multicollinearity, characterized by significant co-expression patterns among genes, often
occurs in high-throughput expression data, potentially impacting the predictive model's …
occurs in high-throughput expression data, potentially impacting the predictive model's …
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
To meet the growing demand for developmental toxicity assessment of chemicals, New
Approach Methodologies (NAMs) are needed. Previously, we developed two 3D in vitro …
Approach Methodologies (NAMs) are needed. Previously, we developed two 3D in vitro …
Bioinformatics Methods for Transcriptome Analysis on Teratogenesis Testing
TW Kowalski, GC Giudicelli, JA Gomes… - … Testing: Methods and …, 2024 - Springer
Teratogenesis testing can be challenging due to the limitations of both in vitro and in vivo
models. Test-systems, based especially on human embryonic cells, have been helping to …
models. Test-systems, based especially on human embryonic cells, have been helping to …
Genes Involved in DNA Repair and Mitophagy Protect Embryoid Bodies from the Toxic Effect of Methylmercury Chloride under Physioxia Conditions
J Augustyniak, H Kozlowska, L Buzanska - Cells, 2023 - mdpi.com
The formation of embryoid bodies (EBs) from human pluripotent stem cells resembles the
early stages of human embryo development, mimicking the organization of three germ …
early stages of human embryo development, mimicking the organization of three germ …