Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

A hallmark of metazoan evolution is the emergence of genomic mechanisms that implement
cell-type-specific functions. However, the evolution of metazoan cell types and their …

Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional
(3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a …

The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …

The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …

Vertebrate genomes are partitioned into contact domains defined by enhanced internal
contact frequency and formed by two principal mechanisms: compartmentalization of …

Abstract The protein Yin Yang 1 (YY1) could form dimers that facilitate the interaction
between active enhancers and promoter-proximal elements. YY1-mediated enhancer …

Orchestrating vertebrate genomes require a complex interplay between the linear
composition of the genome and its 3D organization inside the nucleus. This requires the …

The eukaryotic genome has a hierarchical three-dimensional (3D) organization with
functional implications for DNA replication, DNA repair, and transcriptional regulation. Over …