COVID-19 and thrombosis: From bench to bedside

MAM Ali, SA Spinler - Trends in cardiovascular medicine, 2021 - Elsevier
Abstract Coronavirus disease of 2019 (COVID-19) is the respiratory viral infection caused by
the coronavirus SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus 2). Despite …

[HTML][HTML] Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication

ZY Low, AJW Yip, SK Lal - Biochimica et Biophysica Acta (BBA)-Molecular …, 2022 - Elsevier
Ivermectin (IVM) is an FDA approved macrocyclic lactone compound traditionally used to
treat parasitic infestations and has shown to have antiviral potential from previous in-vitro …

Molecular and biological mechanisms underlying gender differences in COVID-19 severity and mortality

Z Wehbe, SH Hammoud, HM Yassine… - Frontiers in …, 2021 - frontiersin.org
Globally, over two million people have perished due to the recent pandemic caused by
SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher …

RETRACTED: effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic SARS-CoV-2 infected subjects: a pilot clinical trial in Lebanon

AA Samaha, H Mouawia, M Fawaz, H Hassan… - Viruses, 2021 - mdpi.com
Objective: This study was designed to determine the efficacy of ivermectin, an FDA-
approved drug, in producing clinical benefits and decreasing the viral load of SARS-CoV-2 …

Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center …

W Lai, Y Xie, X Zhao, X Xu, S Yu, H Lu, H Huang… - Inflammation …, 2023 - Springer
Background Chronic kidney disease (CKD) is inherently a complex immune-inflammatory
condition, and heightened inflammation and immune dysfunction are closely related to an …

Direct neuronal infection of SARS-CoV-2 reveals cellular and molecular pathology of chemosensory impairment of COVID-19 patients

KS Lyoo, HM Kim, B Lee, YH Che, SJ Kim… - Emerging microbes & …, 2022 - Taylor & Francis
Patients with recent pandemic coronavirus disease 19 (COVID-19) complain of neurological
abnormalities in sensory functions such as smell and taste in the early stages of infection …

Repurposing molnupiravir for COVID-19: the mechanisms of antiviral activity

AJW Yip, ZY Low, VTK Chow, SK Lal - Viruses, 2022 - mdpi.com
Molnupiravir is a β-d-N4-hydroxycytidine-5′-isopropyl ester (NHC) compound that exerts
antiviral activity against various RNA viruses such as influenza, SARS, and Ebola viruses …

Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and In Vitro Study

S Banerjee, S Yadav, S Banerjee… - Journal of chemical …, 2021 - ACS Publications
COVID-19, an acute viral pneumonia, has emerged as a devastating pandemic. Drug
repurposing allows researchers to find different indications of FDA-approved or …

Case report: hyperbilirubinemia in gilbert syndrome attenuates Covid-19-induced metabolic disturbances

HM Al-Kuraishy, AI Al-Gareeb, SM Abdullah… - Frontiers in …, 2021 - frontiersin.org
Gilbert syndrome (GS) is a liver disorder characterized by non-hemolytic unconjugated
hyperbilirubinemia. On the other hand, Coronavirus disease 2019 (Covid-19) is a recent …

SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing

AVW Nunn, GW Guy, W Brysch, SW Botchway… - Immunity & …, 2020 - Springer
Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity,
in particular, with markers of the metabolic syndrome and diabetes, which seems to be …