The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

Our highly seasonal world restricts insect activity to brief portions of the year. This feature
necessitates a sophisticated interpretation of seasonal changes and enactment of …

Sleep is critical for diverse aspects of brain function in animals ranging from invertebrates to
humans. Powerful genetic tools in the fruit fly Drosophila melanogaster have identified—at …

The past twenty years have witnessed the most remarkable breakthroughs in our
understanding of the molecular and cellular mechanisms that underpin circadian …

Many different functions are regulated by circadian rhythms, including those orchestrated by
discrete clock neurons within animal brains. To comprehensively characterize and assign …

The needs fulfilled by sleep are unknown, though the effects of insufficient sleep are
manifold. To better understand how the need to sleep is sensed and discharged, much effort …

Many insects use patterns of polarized light in the sky to orient and navigate. Here, we
functionally characterize neural circuitry in the fruit fly, Drosophila melanogaster, that …