Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
TGF-β: the master regulator of fibrosis
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …
[HTML][HTML] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …
homeostasis, and disease states. However, there is no common consensus on fibroblast …
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin,
but how they target chromatin remains poorly understood. We have used chromatin RNA …
but how they target chromatin remains poorly understood. We have used chromatin RNA …
TGF‐β signaling in cancer
V Syed - Journal of cellular biochemistry, 2016 - Wiley Online Library
The transforming growth factor‐β (TGF‐β) is a family of structurally related proteins that
comprises of TGF‐β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of …
comprises of TGF‐β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of …
Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction
MT Piccoli, SK Gupta, J Viereck, A Foinquinos… - Circulation …, 2017 - Am Heart Assoc
Rationale: Cardiac fibroblasts (CFs) drive extracellular matrix remodeling after pressure
overload, leading to fibrosis and diastolic dysfunction. Recent studies described the role of …
overload, leading to fibrosis and diastolic dysfunction. Recent studies described the role of …
TGF-β/Smad and renal fibrosis
TT Ma, XM Meng - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …
The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
K Zhang, X Han, Z Zhang, L Zheng, Z Hu, Q Yao… - Nature …, 2017 - nature.com
Long noncoding RNAs (lncRNAs) play important roles in various biological processes such
as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA …
as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA …
MEG3: an oncogenic long non-coding RNA in different cancers
A Al-Rugeebah, M Alanazi, NR Parine - Pathology & Oncology Research, 2019 - Springer
Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse
biological processes and emerged as vital players controlling tumorigenesis. Several …
biological processes and emerged as vital players controlling tumorigenesis. Several …
LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging
Z Yang, S Jiang, J Shang, Y Jiang, Y Dai, B Xu… - Ageing research …, 2019 - Elsevier
Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …