[HTML][HTML] Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study
Background Atopic eczema is a common and debilitating condition associated with
depression and anxiety, but the nature of this association remains unclear. Objective To …
depression and anxiety, but the nature of this association remains unclear. Objective To …
[HTML][HTML] Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.
M Mc Elwenspoek, H Thom, AL Sheppard… - Health Technology …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Coeliac disease is an autoimmune disorder triggered by ingesting gluten. It
affects approximately 1% of the UK population, but only one in three people is thought to …
affects approximately 1% of the UK population, but only one in three people is thought to …
[HTML][HTML] Predictive value of inflammatory markers for cancer diagnosis in primary care: a prospective cohort study using electronic health records
Background Early identification of cancer in primary care is important and challenging. This
study examined the diagnostic utility of inflammatory markers (C-reactive protein, erythrocyte …
study examined the diagnostic utility of inflammatory markers (C-reactive protein, erythrocyte …
Concordance with urgent referral guidelines in patients presenting with any of six 'alarm'features of possible cancer: a retrospective cohort study using linked primary …
Background Clinical guidelines advise GPs in England which patients warrant an urgent
referral for suspected cancer. This study assessed how often GPs follow the guidelines …
referral for suspected cancer. This study assessed how often GPs follow the guidelines …
[HTML][HTML] Trends in time to cancer diagnosis around the period of changing national guidance on referral of symptomatic patients: A serial cross-sectional study using …
S Price, A Spencer, X Zhang, S Ball… - Cancer …, 2020 - Elsevier
Background UK primary-care referral guidance describes the signs, symptoms, and test
results (“features”) of undiagnosed cancer. Guidance revision in 2015 liberalised …
results (“features”) of undiagnosed cancer. Guidance revision in 2015 liberalised …
[HTML][HTML] The impact of changing risk thresholds on the number of people in England eligible for urgent investigation for possible cancer: an observational cross …
SF Moore, SJ Price, S Chowienczyk, J Bostock… - British Journal of …, 2021 - nature.com
Background Expediting cancer diagnosis may be achieved by targeted decreases in referral
thresholds to increase numbers of patients referred for urgent investigation. Methods Clinical …
thresholds to increase numbers of patients referred for urgent investigation. Methods Clinical …
Use of multiple inflammatory marker tests in primary care: using Clinical Practice Research Datalink to evaluate accuracy
Background Research comparing C-reactive protein (CRP), erythrocyte sedimentation rate
(ESR), and plasma viscosity (PV) in primary care is lacking. Clinicians often test multiple …
(ESR), and plasma viscosity (PV) in primary care is lacking. Clinicians often test multiple …
[HTML][HTML] Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients …
Background The diagnostic assessment of abdominal symptoms in primary care presents a
challenge. Evidence is needed about the positive predictive values (PPVs) of abdominal …
challenge. Evidence is needed about the positive predictive values (PPVs) of abdominal …
Translating and evaluating historic phenotyping algorithms using SNOMED CT
M Elkheder, A Gonzalez-Izquierdo… - Journal of the …, 2023 - academic.oup.com
Objective Patient phenotype definitions based on terminologies are required for the
computational use of electronic health records. Within UK primary care research databases …
computational use of electronic health records. Within UK primary care research databases …
[HTML][HTML] The association between menstrual cycle characteristics and cardiometabolic outcomes in later life: a retrospective matched cohort study of 704,743 women …
Background Female reproductive factors are gaining prominence as factors that enhance
cardiovascular disease (CVD) risk; nonetheless, menstrual cycle characteristics are under …
cardiovascular disease (CVD) risk; nonetheless, menstrual cycle characteristics are under …