The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling

S Backert, R Haas, M Gerhard, M Naumann - Type IV Secretion in Gram …, 2017 - Springer
Various gram-negative pathogens express type IV secretion systems (T4SSs) which
translocate bacterial virulence factors into host target cells to hijack cellular processes for …

In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System

B Hu, P Khara, L Song, AS Lin, AE Frick-Cheng… - MBio, 2019 - Am Soc Microbiol
Helicobacter pylori colonizes about half of humans worldwide, and its presence in the
gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric …

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

MJ Sheedlo, JM Chung, N Sawhney, CL Durie… - Elife, 2020 - elifesciences.org
The pathogenesis of Helicobacter pylori-associated gastric cancer is dependent on delivery
of CagA into host cells through a type IV secretion system (T4SS). The H. pylori Cag T4SS …

Roles of the components of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori

L Gou, X Yang, J Yun, Z Ma, X Zheng, H Du… - Future …, 2024 - Taylor & Francis
The Helicobacter pylori (H. pylori) cytotoxin-associated gene pathogenicity island (cag PAI)
encodes 31 genes that assemble the cag type IV secretion system (T4SS) apparatus, which …

Structural insights into the assembly pathway of the Helicobacter pylori CagT4SS outer membrane core complex

CY Mok, HY Chu, WWL Lam, SWN Au - Structure, 2024 - cell.com
Cag type IV secretion system (CagT4SS) translocates oncoprotein cytotoxin-associated
gene A (CagA) into host cells and plays a key role in the pathogenesis of Helicobacter …

Analyse biochimique et inhibition de complexes macromoléculaires dans des cellules humaines et bactériennes

F Oudouhou - 2019 - papyrus.bib.umontreal.ca
Les complexes macromoléculaires sont au cœur des processus fondamentaux de la cellule.
L'étude de leur composition, de leur structure et des interactions qui s' exercent entre leurs …