Metabolic adaptation of lymphocytes in immunity and disease

NM Chapman, H Chi - Immunity, 2022 - cell.com
Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Selenium and selenoproteins in health

F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis

J Xu, T Chu, T Yu, N Li, C Wang, C Li, Y Zhang… - Acs Nano, 2022 - ACS Publications
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel
disease (IBD), is responsible for dysregulation of signal transduction, inflammatory …

Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors

J Wu, Y Li, Y Huang, L Liu, H Zhang, C Nagy… - Nature …, 2023 - nature.com
Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy

X Pan, Q Zhu, LL Pan, J Sun - Pharmacology & therapeutics, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …

Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

H Wang, N Li, Q Liu, J Guo, Q Pan, B Cheng, J Xu… - Cancer Cell, 2023 - cell.com
Lineage plasticity causes therapeutic resistance; however, it remains unclear how the fate
conversion and phenotype switching of cancer-associated fibroblasts (CAFs) are implicated …

Translational selenium nanoparticles to attenuate allergic dermatitis through Nrf2-Keap1-driven activation of selenoproteins

B Xie, D Zeng, M Yang, Z Tang, L He, T Chen - ACS nano, 2023 - ACS Publications
Easy recurrence and strong treatment side effects significantly limit the clinical treatment of
allergic dermatitis. The human trace element selenium (Se) plays essential roles in redox …

Selenium‐containing type‐I organic photosensitizers with dual reactive oxygen species of superoxide and hydroxyl radicals as switch‐hitter for photodynamic therapy

H Wang, T Qin, W Wang, X Zhou, F Lin… - Advanced …, 2023 - Wiley Online Library
Organic type‐I photosensitizers (PSs) which produce aggressive reactive oxygen species
(ROS) with less oxygen‐dependent exhibit attractive curative effect for photodynamic …

The role and mechanism of essential selenoproteins for homeostasis

R Ye, J Huang, Z Wang, Y Chen, Y Dong - Antioxidants, 2022 - mdpi.com
Selenium (Se) is one of the essential trace elements that plays a biological role in the body,
mainly in the form of selenoproteins. Selenoproteins can be involved in the regulation of …

[HTML][HTML] Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis

L Hou, F Gong, B Liu, X Yang, L Chen, G Li, Y Gong… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Oxidative stress, resulting from excessive reactive oxygen species (ROS), plays
an important role in the initiation and progression of inflammatory bowel disease (IBD) …