T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
[HTML][HTML] Emerging evidence for adapting radiotherapy to immunotherapy
L Galluzzi, MJ Aryankalayil, CN Coleman… - Nature reviews Clinical …, 2023 - nature.com
Immunotherapy has revolutionized the clinical management of many malignancies but is
infrequently associated with durable objective responses when used as a standalone …
infrequently associated with durable objective responses when used as a standalone …
[HTML][HTML] Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
R Polak, ET Zhang, CJ Kuo - Nature Reviews Cancer, 2024 - nature.com
The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
[HTML][HTML] Localization, tissue biology and T cell state—implications for cancer immunotherapy
JM Schenkel, KE Pauken - Nature Reviews Immunology, 2023 - nature.com
Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …
dependent killers, which requires them to physically be within the tissue of interest to kill …
[HTML][HTML] Stem-like exhausted and memory CD8+ T cells in cancer
T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
SE Brightman, A Becker, RR Thota, MS Naradikian… - Nature …, 2023 - nature.com
CD4+ T cells play key roles in a range of immune responses, either as direct effectors or
through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg) …
through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg) …
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness
H Cheng, Y Qiu, Y Xu, L Chen, K Ma, M Tao… - Nature …, 2023 - nature.com
The accumulation of acidic metabolic waste products within the tumor microenvironment
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …
BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1
Q Sun, D Cai, D Liu, X Zhao, R Li, W Xu, B Xie… - Science …, 2023 - science.org
Overcoming CD8+ T cell exhaustion is critical in cancer immunotherapy. Recently, an
intratumor stem/progenitor-like CD8+ T cell (Tprog cell) population that mediates the …
intratumor stem/progenitor-like CD8+ T cell (Tprog cell) population that mediates the …