Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and
systemic inflammation where the close interaction between immune cells and soluble …

White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis
and triglyceride storage. It is now considered as an active organ secreting a plethora of …

Many studies have reported that patients with psychosis, even before drug treatment, have
mildly raised levels of blood cytokines relative to healthy controls. In contrast, there is a …

The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …

Autoimmune diseases affect many people worldwide. Current treatment modalities focus on
the reduction of disease symptoms using anti-inflammatory drugs which can lead to side …

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple organ systems
and is characterized by skin and joint manifestations. PsA is frequently undiagnosed and/or …

Adipokines are the principal mediators in adipose signaling. Nevertheless, besides their role
in energy storage, these molecules can be produced by other cells, such as immune cells or …