The ability to detect pathogenic and physiologically relevant molecules in the body with high
sensitivity and specificity offers a powerful opportunity in the early diagnosis and treatment of …

Aptamers have become coming-of-age molecular recognition elements in both diagnostic
and therapeutic applications. Generated by SELEX, the 'quality control'of aptamers, which …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Circular dichroism (CD) spectroscopy is an optical technique that measures the difference in
the absorption of left and right circularly polarized light. This technique has been widely …

Covering: 1980 to 2011 Major groove recognition of DNA by proteins utilizes the variation in
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …

In order to determine the health status of people and provide the most appropriate treatment,
rapid and accurate diagnosis is required. Recently all the clinical analysis is piloted in …

A DNA duplex can be recognized sequence-specifically in the major groove by an
oligodeoxynucleotide (ODN). The resulting structure is a DNA triple helix, or triplex. The …

A dimeric neomycin− neomycin conjugate 3 with a flexible linker, 2, 2′-(ethylenedioxy) bis
(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT …

Recognition of nucleic acids is important for our understanding of nucleic acid structure as
well as for our understanding of nucleic acid–protein interactions. In addition to the direct …

A series of neomycin dimers have been synthesized using “click chemistry” with varying
functionality and length in the linker region to target the human immunodeficiency virus type …