Among the central goals of stress neurobiology research is to understand the mechanisms
by which stressors change neural circuit function to precipitate or exacerbate psychiatric …

The sucrose preference test (SPT) is a widely used preclinical assay for studying stress-
sensitive reward behaviors and antidepressant treatments in rodents, with some face …

Depression is a complicated neuropsychiatric condition with an incompletely understood
etiology, making the discovery of effective therapies challenging. Animal models have been …

Context Crocin exhibits anti-depressant properties. However, its underlying mechanisms
and its relationship with metabolomics remain unclear. Objective This study elucidates the …

Chronic pain and alcohol use disorder (AUD) are highly comorbid, and patients with chronic
pain are more likely to meet the criteria for AUD. Evidence suggests that both conditions …

Apathy is the most common behavioural and psychological symptom in Alzheimer's disease
(AD) and other neurodegenerative diseases including frontotemporal dementia (FTD) and …

Introduction Our previous work reveals a critical role of activation of neuronal Alox5 in
exacerbating brain injury post seizures. However, whether neuronal Alox5 impacts the …

Repeated reward intake decreases its subjective pleasantness, which is a common
phenomenon called reward devaluation. In this issue of Neuron, Yuan et al. 1 unravel that …

Dear Editor, In response to Berrio, JP, Hestehave, S. & Kalliokoski, O. Reliability of sucrose
preference testing following short or no food and water deprivation—a Systematic Review …

Anhedonia is a core symptom of major depressive disorder (MDD) and is associated with
worse treatment outcomes. While its narrow definition as a hedonic or consummatory deficit …