Traditional organic synthesis relies heavily on organic solvents for a multitude of tasks,
including dissolving the components and facilitating chemical reactions, because many …

In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …

Chirality is a basic characteristic of living matter and nature. During the evolution of life on
our planet, nature has favored one kind of chirality, thereby selecting the l-amino acids (with …

The design of artificial catalysts able to compete with the catalytic proficiency of enzymes is
an intense subject of research. Non-covalent interactions are thought to be involved in …

The metal-catalyzed asymmetric conjugate addition (ACA) reaction has emerged as a
general and powerful approach for the construction of optically active compounds and is …

Gene editing is an important genetic engineering technique that enables gene manipulation
at the molecular level. It mainly relies on engineered nucleases of biological origin, whose …

Enzymes are nanometer-sized molecules with three-dimensional structures created by the
folding and self-assembly of polymeric chain-like components through supramolecular …

Oxa-Michael reactions, ie addition reactions of oxygen nucleophiles to conjugated systems,
have traditionally received much less attention from the scientific community compared to …

Chiral recognition is of importance not only in living systems but also in estimating the
optical purity of enantiomeric drugs and fabricating advanced materials. Herein we report a …

Conspectus The biotechnological revolution has made it possible to create enzymes for
many reactions by directed evolution. However, because of the immense number of …