[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
CTCF shapes chromatin structure and gene expression in health and disease
B Dehingia, M Milewska, M Janowski, A Pękowska - EMBO reports, 2022 - embopress.org
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
Visualizing DNA folding and RNA in embryos at single-cell resolution
The establishment of cell types during development requires precise interactions between
genes and distal regulatory sequences. We have a limited understanding of how these …
genes and distal regulatory sequences. We have a limited understanding of how these …
RNA interactions are essential for CTCF-mediated genome organization
R Saldaña-Meyer, J Rodriguez-Hernaez, T Escobar… - Molecular cell, 2019 - cell.com
The function of the CCCTC-binding factor (CTCF) in the organization of the genome has
become an important area of investigation, but the mechanisms by which CTCF dynamically …
become an important area of investigation, but the mechanisms by which CTCF dynamically …
Topologically associating domain boundaries are required for normal genome function
Topologically associating domain (TAD) boundaries partition the genome into distinct
regulatory territories. Anecdotal evidence suggests that their disruption may interfere with …
regulatory territories. Anecdotal evidence suggests that their disruption may interfere with …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD architecture
A Despang, R Schöpflin, M Franke, S Ali, I Jerković… - Nature …, 2019 - nature.com
The genome is organized in three-dimensional units called topologically associating
domains (TADs), through a process dependent on the cooperative action of cohesin and the …
domains (TADs), through a process dependent on the cooperative action of cohesin and the …
Static and dynamic DNA loops form AP-1-bound activation hubs during macrophage development
The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …
structural and regulatory chromatin loops important for coordinating changes in transcription …
Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates
Y Hara, K Yamaguchi, K Onimaru, M Kadota… - Nature ecology & …, 2018 - nature.com
Modern cartilaginous fishes are divided into elasmobranchs (sharks, rays and skates) and
chimaeras, and the lack of established whole-genome sequences for the former has …
chimaeras, and the lack of established whole-genome sequences for the former has …
Comparison of computational methods for the identification of topologically associating domains
M Zufferey, D Tavernari, E Oricchio, G Ciriello - Genome biology, 2018 - Springer
Background Chromatin folding gives rise to structural elements among which are clusters of
densely interacting DNA regions termed topologically associating domains (TADs). TADs …
densely interacting DNA regions termed topologically associating domains (TADs). TADs …