The war against heart failure: the Lancet lecture
E Braunwald - The Lancet, 2015 - thelancet.com
Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …
worldwide, a number that is increasing with the ageing of the population. It is the most …
[HTML][HTML] Advanced human developmental toxicity and teratogenicity assessment using human organoid models
M Li, J Gong, L Gao, T Zou, J Kang, H Xu - … and Environmental Safety, 2022 - Elsevier
Tremendous progress has been made in the field of toxicology leading to the advance of
developmental toxicity assessment. Conventional animal models and in vitro two …
developmental toxicity assessment. Conventional animal models and in vitro two …
Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes
L Zhao, B Zhang - Scientific reports, 2017 - nature.com
Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients.
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …
Nanotopography-induced structural anisotropy and sarcomere development in human cardiomyocytes derived from induced pluripotent stem cells
Understanding the phenotypic development of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy …
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy …
Modeling doxorubicin-induced cardiotoxicity in human pluripotent stem cell derived-cardiomyocytes
A Maillet, K Tan, X Chai, SN Sadananda, A Mehta… - Scientific reports, 2016 - nature.com
Doxorubicin is a highly efficacious anti-cancer drug but causes cardiotoxicity in many
patients. The mechanisms of doxorubicin-induced cardiotoxicity (DIC) remain incompletely …
patients. The mechanisms of doxorubicin-induced cardiotoxicity (DIC) remain incompletely …
Signaling cascades in the failing heart and emerging therapeutic strategies
X He, T Du, T Long, X Liao, Y Dong… - Signal transduction and …, 2022 - nature.com
Chronic heart failure is the end stage of cardiac diseases. With a high prevalence and a high
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …
mortality rate worldwide, chronic heart failure is one of the heaviest health-related burdens …
Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering
JH Tsui, NA Ostrovsky-Snider, DMP Yama… - Journal of materials …, 2018 - pubs.rsc.org
We report on the development of bioinspired cardiac scaffolds made from electroconductive
acid-modified silk fibroin–poly (pyrrole)(AMSF+ PPy) substrates patterned with nanoscale …
acid-modified silk fibroin–poly (pyrrole)(AMSF+ PPy) substrates patterned with nanoscale …
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise
Aging is typified by a gradual loss of physiological fitness and accumulation of cellular
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …
damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging …
The effect of PVDF‐TrFE scaffolds on stem cell derived cardiovascular cells
Recently, electrospun polyvinylidene fluoride (PVDF) and polyvinylidene fluoride‐
trifluoroethylene (PVDF‐TrFE) scaffolds have been developed for tissue engineering …
trifluoroethylene (PVDF‐TrFE) scaffolds have been developed for tissue engineering …
Human cardiomyocyte generation from pluripotent stem cells: A state-of-art
The human heart is considered a non-regenerative organ. Worldwide, cardiovascular
diseases continue to be the leading cause of death. Despite advances in cardiac treatment …
diseases continue to be the leading cause of death. Despite advances in cardiac treatment …