β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Candida albicans is the most common pathogen causing clinical Candida infections.
Neutrophils are a key member of the host innate immunity that plays an essential role in …

Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps
(NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been …

Metastasis has been one of the primary reasons for the high mortality rates associated with
tumours in recent years, rendering the treatment of current malignancies challenging and …

The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Common causes include gram-negative and gram-positive bacteria as …

Neutrophil extracellular trap (NET) formation requires chromatin decondensation before
nuclear swelling and eventual extracellular release of DNA, which occurs together with …

Wound healing is a complex sequence of tissue protection, replacement, and reorganization
leading to regenerated tissue. Disruption of any of these steps results in the process being …

Neutrophils are an important source of interleukin (IL)-1β and other cytokines because they
are recruited to sites of infection and inflammation in high numbers. Although secretion of …

Recent evidence suggests that targeting S100A9 reduces pathological inflammation in
abdominal sepsis. Herein, we investigated the role of S100A9 in neutrophil extracellular trap …