Spatially Fractionated Radiation therapy (SFRT) has a history of over 100 years. The
principle of SFRT is distinctive from the standard radiation approaches, as it treats the total …

Total radiation dose is not a reliable measure of biological effect when dose-per-fraction or
dose-rate is changed. Large differences in biological effectiveness (per gray) are seen …

Purpose To determine if escalated radiation dose using hypofractionation significantly
reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for …

PURPOSE: There are reports of a high sensitivity of prostate cancer to radiotherapy dose
fractionation, and this has prompted several trials of hypofractionation schedules. It remains …

From background physics and biological models to the latest imaging and treatment
modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all …

Recent results from animal irradiation studies have demonstrated the potential of ultra-high
dose rate irradiation (also known as FLASH) for reducing radiation toxicity in normal tissues …

A great deal of quantitative information regarding the dose–volume relationships of pelvic
organs at risk has been collected and analysed over the last 10 years. The need to improve …

Radiation quality and cellular oxygen concentration have a substantial impact on DNA
damage, reproductive cell death and, ultimately, the potential efficacy of radiation therapy for …

Purpose The optimal radiation dose fractionation schedule for localized prostate cancer is
unclear. This study was designed to compare two dose fractionation schemes (a shorter 4 …

Background The treatment results of external beam radiotherapy for intermediate and high
risk prostate cancer patients are insufficient with five-year biochemical relapse rates of …