Ischemic stroke continues to be one of the most challenging diseases in translational
neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for …

Intracerebral hemorrhagic transformation (HT) is well recognized as a common cause of
hemorrhage in patients with ischemic stroke. HT after acute ischemic stroke contributes to …

Treatment efficacy for ischemic stroke represents a major challenge. Despite fundamental
advances in the understanding of stroke etiology, therapeutic options to improve functional …

Stroke remains the fifth leading cause of mortality in the United States with an annual rate of
over 128,000 deaths per year. Differences in incidence, pathogenesis, and clinical outcome …

Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters
and some risk factors. The relations between two main players in the ischemic brain, MMPs …

Thrombolysis is recommended for reperfusion following acute ischemic stroke (AIS), but its
effects on stroke-associated injury remain to be clarified. Here, we investigated the effects of …

Aims To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9
expression and spinal cord edema after acute spinal cord injury (SCI). Main methods Ninety …

Basement membrane degradation and blood-brain barrier damage appear after cerebral
infarction, severely impacting neuronal and brain functioning; however, the underlying …

Inflammation and immune response play a pivotal role in the pathophysiology of ischemic
stroke giving their contribution to tissue damage and repair. Emerging evidence supports the …

Background Molecular biomarkers have revolutionalized diagnosis and treatment of many
diseases, such as troponin use in myocardial infarction. Urgent need for high-fidelity …