This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

Rationale: Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively,
are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient …

Key points Endothelial cell function in resistance arteries integrates Ca2+ signalling with
hyperpolarization to promote relaxation of smooth muscle cells and increase tissue blood …

Vascular endothelial cells, as well as smooth muscle cells, show heterogeneity with regard
to their receptor expression and reactivity. For the vascular wall to act as a functional unit …

Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ
function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli …

Background: Ischemic heart disease has long been considered to be exlusively caused by
stenosis or occlusion. However, the coronary microcirculation too may play an important role …

Vasomotor responses conduct among resistance arteries to coordinate blood flow delivery
pursuant to energetic demand. Conduction is set by the electrical and mechanical properties …

The physiology of biological structures is inherently dynamic and emerges from the
interaction and assembly of large collections of small entities. The extent of coupled entities …