Allosteric cascade of spliceosome activation
DA Brow - Annual review of genetics, 2002 - annualreviews.org
▪ Abstract Introns are removed from precursor messenger RNAs in the cell nucleus by a
large ribonucleoprotein complex called the spliceosome. The spliceosome contains five …
large ribonucleoprotein complex called the spliceosome. The spliceosome contains five …
Nucleic acid catalysis: metals, nucleobases, and other cofactors
WL Ward, K Plakos, VJ DeRose - Chemical reviews, 2014 - ACS Publications
The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …
An atomic structure of the human spliceosome
Mechanistic understanding of pre-mRNA splicing requires detailed structural information on
various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) …
various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) …
Structure of a yeast activated spliceosome at 3.5 Å resolution
Pre–messenger RNA (pre-mRNA) splicing is carried out by the spliceosome, which
undergoes an intricate assembly and activation process. Here, we report an atomic structure …
undergoes an intricate assembly and activation process. Here, we report an atomic structure …
RNA catalyses nuclear pre-mRNA splicing
SM Fica, N Tuttle, T Novak, NS Li, J Lu, P Koodathingal… - Nature, 2013 - nature.com
In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic
machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years …
machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years …
Structure of a yeast spliceosome at 3.6-angstrom resolution
Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome,
which consists of five small nuclear ribonucleoproteins (snRNPs), NTC (nineteen complex) …
which consists of five small nuclear ribonucleoproteins (snRNPs), NTC (nineteen complex) …
Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing
Long introns with short exons in vertebrate genes are thought to require spliceosome
assembly across exons (exon definition), rather than introns, thereby requiring transcription …
assembly across exons (exon definition), rather than introns, thereby requiring transcription …
Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution
Each cycle of pre–messenger RNA splicing, carried out by the spliceosome, comprises two
sequential transesterification reactions, which result in the removal of an intron and the …
sequential transesterification reactions, which result in the removal of an intron and the …
The 3.8 Å structure of the U4/U6. U5 tri-snRNP: Insights into spliceosome assembly and catalysis
R Wan, C Yan, R Bai, L Wang, M Huang, CCL Wong… - Science, 2016 - science.org
Splicing of precursor messenger RNA is accomplished by a dynamic megacomplex known
as the spliceosome. Assembly of a functional spliceosome requires a preassembled U4/U6 …
as the spliceosome. Assembly of a functional spliceosome requires a preassembled U4/U6 …