Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Decreased hepcidin mobilizes iron, which facilitates erythropoiesis, but excess iron is
pathogenic in β-thalassemia. Erythropoietin (EPO) enhances erythroferrone (ERFE) …

Erythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone
controlling plasma iron levels and total body iron. When the release of erythropoietin from …

Iron deficiency, with or without anemia, is extremely frequent worldwide, representing a
major public health problem. Iron replacement therapy dates back to the seventeenth …

Erythropoiesis is the predominant consumer of iron in humans and other vertebrates. By
decreasing the transcription of the gene encoding the iron-regulatory hormone hepcidin …

The erythroid marrow and circulating red blood cells (RBCs) are the key components of the
human erythron. Abnormalities of the erythron that are responsible for anemia can be …

Abstract β-Thalassemia (BT) is an inherited genetic disorder that is characterized by
ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism. IE is an …

Iron is an essential micronutrient for oxygen transport, cellular energy metabolism, and many
enzymatic reactions. Complex physiological processes have evolved for iron acquisition to …

Polycythemia vera (PV) is a chronic myeloproliferative neoplasm. Virtually all PV patients
are iron deficient at presentation and/or during the course of their disease. The co-existence …