Arrhythmias in the developing heart

D Sedmera, R Kockova, F Vostarek… - Acta …, 2015 - Wiley Online Library
Prevalence of cardiac arrhythmias increases gradually with age; however, specific rhythm
disturbances can appear even prior to birth and markedly affect foetal development …

Effect of Remote Ischemic Preconditioning on Phosphorylated Protein Signaling in Children Undergoing Tetralogy of F allot Repair: A Randomized Controlled Trial

S Pepe, NY Liaw, M Hepponstall… - Journal of the …, 2013 - Am Heart Assoc
Background Our previous randomized controlled trial demonstrated cardiorespiratory
protection by remote ischemic preconditioning (RIPC) in children before cardiac surgery …

STAT3α interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart

S Pedretti, E Raddatz - Basic research in cardiology, 2011 - Springer
Abstract Activation of the Janus Kinase 2/Signal Transducer and Activator of Transcription 3
(JAK2/STAT3) pathway is known to play a key role in cardiogenesis and to afford …

Differential contribution of mitochondria, NADPH oxidases, and glycolysis to region-specific oxidant stress in the anoxic-reoxygenated embryonic heart

E Raddatz, AC Thomas, A Sarre… - American Journal of …, 2011 - journals.physiology.org
The ability of the developing myocardium to tolerate oxidative stress during early gestation is
an important issue with regard to possible detrimental consequences for the fetus. In the …

Adenosine A1 receptor activation is arrhythmogenic in the developing heart through NADPH oxidase/ERK-and PLC/PKC-dependent mechanisms

E Robin, J Sabourin, R Benoit, S Pedretti… - Journal of molecular and …, 2011 - Elsevier
Whether adenosine, a crucial regulator of the developing cardiovascular system, can
provoke arrhythmias in the embryonic/fetal heart remains controversial. Here, we aimed to …

Involvement of CD73, equilibrative nucleoside transporters and inosine in rhythm and conduction disturbances mediated by adenosine A1 and A2A receptors in the …

E Robin, J Sabourin, F Marcillac, E Raddatz - Journal of molecular and …, 2013 - Elsevier
We previously established that exogenous adenosine (ADO) induces transient arrhythmias
in the developing heart via the adenosine A1 receptor (A 1 AR) and downstream activation …

A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance

E Robin, F Marcillac, E Raddatz - American Journal of …, 2015 - journals.physiology.org
To what extent hypoxia alters the adenosine (ADO) system and impacts on cardiac function
during embryogenesis is not known. Ectonucleoside triphosphate diphosphohydrolase …

Heat shock-induced apoptosis

IM Mahajan - 2013 - repositories.lib.utexas.edu
Apoptosis is a conserved program of cell death that promotes organism homeostasis in all
stages of life. Two main pathways activate caspases, which are cysteinyl-aspartate …