Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …

The fragile X syndrome, an X-linked dominant disorder with reduced penetrance, is one of
the most common forms of inherited mental retardation. The cognitive, behavioral, and …

Fragile X syndrome arises from blocked expression of the fragile X mental retardation
protein (FMRP). Golgi-impregnated mature cerebral cortex from fragile X patients exhibits …

Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental
retardation syndrome. FMRP harbors three RNA binding domains, associates with …

Fragile X syndrome is the result of transcriptional suppression of the gene FMR1 as a result
of a trinucleotide repeat expansion mutation. The normal function of the FMR1 protein …

Fragile‐X syndrome is a common form of mental retardation resulting from the inability to
produce the fragile‐X mental retardation protein. Qualitative examination of human brain …

Male patients with fragile X syndrome lack FMR1 protein due to silencing of the FMR1 gene
by amplification of a CGG repeat and subsequent methylation of the promoter region. The …

Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability.
Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of …

Fragile X mental retardation syndrome is caused by the unstable expansion of a CGG repeat
in the FMR–1 gene. In patients with a full mutation, abnormal methylation results in …

Fragile X syndrome (FXS) is the most common form of inherited mental retardation, and it is
caused by loss of function of the fragile X mental retardation protein (FMRP). FMRP is an …