OXA-48-like β-lactamases: global epidemiology, treatment options, and development pipeline

SE Boyd, A Holmes, R Peck… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The crisis of carbapenemase-mediated carbapenem resistance across the human–animal–environmental interface in India

S Das - Infectious Diseases Now, 2023 - Elsevier
Carbapenems are the decision-making antimicrobials used to combat severe Gram-
negative bacterial infections in humans. Carbapenem resistance poses a potential public …

[HTML][HTML] Variations of antibiotic resistome in swine wastewater during full-scale anaerobic digestion treatment

M Zhang, YS Liu, JL Zhao, WR Liu, J Chen… - Environment …, 2021 - Elsevier
Anaerobic digesters have been widely used to treat wastewaters in livestock farms. With the
increasing risk of antibiotic resistance originated from livestock husbandry, removal of …

Metagenomic insight into microbiome and antibiotic resistance genes of high clinical concern in urban and rural hospital wastewater of northern India origin: a major …

A Talat, KS Blake, G Dantas, AU Khan - Microbiology spectrum, 2023 - Am Soc Microbiol
India is one of the largest consumers and producers of antibiotics and a hot spot for the
emergence and proliferation of antimicrobial resistance genes (ARGs). Indian hospital …

[HTML][HTML] Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae

S David, JLC Wong, J Sanchez-Garrido… - PLoS …, 2022 - journals.plos.org
Mutations in outer membrane porins act in synergy with carbapenemase enzymes to
increase carbapenem resistance in the important nosocomial pathogen, Klebsiella …

Carbapenem-resistant Klebsiella pneumoniae: the role of plasmids in emergence, dissemination, and evolution of a major clinical challenge

V Di Pilato, S Pollini, V Miriagou… - Expert Review of Anti …, 2024 - Taylor & Francis
Introduction Klebsiella pneumoniae is a major agent of healthcare-associated infections and
a cause of some community-acquired infections, including severe bacteremic infections …

OXA-181-like carbapenemases in Klebsiella pneumoniae ST14, ST15, ST23, ST48, and ST231 from septicemic neonates: coexistence with NDM-5, resistome …

S Naha, K Sands, S Mukherjee, B Saha, S Dutta… - MSphere, 2021 - Am Soc Microbiol
Studies on the epidemiology and genomes of isolates harboring OXA-48-like genes in
septicemic neonates are rare. Here, isolates producing these carbapenemases which …

High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study

G Nagaraj, V Shamanna, V Govindan… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a threat to
public health in India because of its high dissemination, mortality, and limited treatment …

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in …

B Isler, B Özer, G Çınar, AT Aslan, C Vatansever… - European Journal of …, 2022 - Springer
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella
spp.(CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019 …

[HTML][HTML] Emergence of K1 ST23 and K2 ST65 hypervirulent klebsiella pneumoniae as true pathogens with specific virulence genes in cryptogenic pyogenic liver …

M Sohrabi, M Alizade Naini, A Rasekhi… - Frontiers in Cellular …, 2022 - frontiersin.org
Hypervirulent Klebsiella pneumoniae (hvKp) pathotype is emerging worldwide in pyogenic
liver abscesses (PLAs). However, the role of virulence factors in pathogenicity remains …