Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis …

Background: Second-generation antidepressants dominate the management of major
depressive disorder (MDD), but evidence on the comparative benefits and harms of these …

The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and
specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic α2 …

Background: Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs),
venlafaxine, and clomipramine, are frequently associated with sexual dysfunction. Other …

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic
advance in psychopharmacology. As a result, the discovery of these agents marks a …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety
disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

Clinical researchers have turned their attention to quality of life assessment as a means of
broadening the evaluation of treatment outcomes. This article examines conceptual and …

Background Mirtazapine has a unique mechanism of antidepressive action and is one of the
commonly used antidepressants in clinical practice. Objectives The aim of the present …