Abstract Development and differentiation of the thyroid gland is directed by expression of
specific transcription factors in the thyroid follicular cell which mediates hormone …

The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …

Genetic defects in the thyroid hormone transporter monocarboxylate transporter 8 (MCT8)
result in MCT8 deficiency. This disorder is characterized by a combination of severe …

Background and objectives MCT8 deficiency is a rare genetic leukoencephalopathy caused
by a defect of thyroid hormone transport across cell membranes, particularly through blood …

Background Disordered thyroid hormone transport, due to mutations in the SLC16A2 gene
encoding monocarboxylate transporter 8 (MCT8), is characterised by intellectual and motor …

Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the
SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a …

Abstract Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder that causes
severe neurological damage, for which there is no effective treatment. AHDS is due to …

Monocarboxylate transporter 8 (MCT8) deficiency or the Allan-Herndon-Dudley Syndrome
(AHDS) is an X-linked psychomotor disability syndrome with around 320 clinical cases …

Defective thyroid hormone transport due to deficiency in thyroid hormone transporter
monocarboxylate transporter 8 (MCT8) results in severe neurodevelopmental delay due to …

Background Studies suggest that thyroid peroxidase antibody (TPOAb) positivity exposure
during pregnancy may contribute to changes in placental morphology and pathophysiology …