Evaluation of the stability of drugs and drug metabolites in a biological matrix is a critical
element to bioanalytical method validation. It is critical to understand the most common …

Recent years have witnessed the introduction of several high-quality review articles into the
literature covering various scientific and technical aspects of bioanalysis. Now it is widely …

A quantitative method for the determination of clopidogrel active metabolite (AM) in human
plasma was developed and validated using liquid chromatography–tandem mass …

The intention of this study was to compare the physicochemical properties, stability and
bioavailability of a clopidogrel napadisilate (CN)-loaded solid dispersion (SD) and solid self …

The purpose of this study is to develop solid self-nanoemulsifying drug delivery systems (S-
SNEDDS) for oral bioavailability enhancement of Clopidogrel (CLP). CLP is an anti-platelet …

Background Diabetes mellitus is a chronic metabolic disease characterized by increased
blood glucose levels. In order to lower blood glucose, it is important to stimulate glucose …

Herein, an albumin-enriched nanocomplex was developed for the solubilization and
intravascular administration of clopidogrel bisulfate (CLP). In particular, CLP nanoparticles …

Purpose Cerebral ischemia–reperfusion (I/R) injury remains a leading cause of mobility and
mortality among patients with ischemic stroke. This study aims to develop a human serum …

A new, simple, and reproducible method for determination of carboxylic acid metabolite of
clopidogrel in human plasma has been developed. After liquid–liquid extraction in acidic …

A fast, sensitive and specific LC–MS/MS bioanalytical method for the determination of
unchanged clopidogrel in human plasma has been developed and validated over the range …