S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Neurological disorders (ND) are the central nervous system (CNS) related complications
originated by enhanced oxidative stress, mitochondrial failure and overexpression of …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Inhibition of amyloid β peptide (Aβ) aggregation is an important goal due to the connection
of this process with Alzheimer's disease. Traditionally, inhibitors were developed with an aim …

The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele
associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement …

Molecular chaperones are important components in the cellular quality-control machinery
and increasing evidence points to potential new roles for them as suppressors of amyloid …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form …

The microtubule-associated protein tau is implicated in the formation of oligomers and
fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau …

S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

Simple Summary This review presents the beginning of the history of toxic properties of
amyloids, especially on Aβ amyloids. We discuss anti-amyloid therapy and its problems and …