Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
[HTML][HTML] Using genetic association data to guide drug discovery and development: review of methods and applications
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …
expensive and slow to obtain. In contrast, evidence from conventional observational …
Guidelines for performing Mendelian randomization investigations: update for summer 2023 [version 3; peer review: 2 approved]
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
aimed at practitioners seeking to undertake analyses and write up their findings, and at …
[HTML][HTML] Statistical methods for Mendelian randomization in genome-wide association studies: a review
Genome-wide association studies have yielded thousands of associations for many
common diseases and disease-related complex traits. The identified associations made it …
common diseases and disease-related complex traits. The identified associations made it …
Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study
Z Wei, B Yang, T Tang, Z Xiao, F Ye, X Li… - Cancer …, 2023 - Wiley Online Library
Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …
Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach
The rising prevalence of childhood obesity has been postulated as an explanation for the
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …
[HTML][HTML] Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
We conduct proteome-wide Mendelian randomization and colocalization analyses to
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study
D Freuer, J Linseisen, C Meisinger - BMC medicine, 2022 - Springer
Background The question of whether asthma is causally related to gastrointestinal disorders
remained unanswered so far. Thus, this study investigated whether there is such a relation …
remained unanswered so far. Thus, this study investigated whether there is such a relation …
Socioeconomic status, individual behaviors and risk for mental disorders: a Mendelian randomization study
J Cai, Z Wei, M Chen, L He, H Wang, M Li… - European …, 2022 - cambridge.org
Background There is increasing attention on the association of socioeconomic status and
individual behaviors (SES/IB) with mental health. However, the impacts of SES/IB on mental …
individual behaviors (SES/IB) with mental health. However, the impacts of SES/IB on mental …
Interpretation of Mendelian randomization using a single measure of an exposure that varies over time
TT Morris, J Heron, ECM Sanderson… - International Journal …, 2022 - academic.oup.com
Background Mendelian randomization (MR) is a powerful tool through which the causal
effects of modifiable exposures on outcomes can be estimated from observational data. Most …
effects of modifiable exposures on outcomes can be estimated from observational data. Most …