Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

[HTML][HTML] Using genetic association data to guide drug discovery and development: review of methods and applications

S Burgess, AM Mason, AJ Grant, EAW Slob… - The American Journal of …, 2023 - cell.com
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Guidelines for performing Mendelian randomization investigations: update for summer 2023 [version 3; peer review: 2 approved]

S Burgess, G Davey Smith, NM Davies… - Wellcome open …, 2023 - discovery.ucl.ac.uk
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

[HTML][HTML] Statistical methods for Mendelian randomization in genome-wide association studies: a review

FJ Boehm, X Zhou - Computational and structural biotechnology journal, 2022 - Elsevier
Genome-wide association studies have yielded thousands of associations for many
common diseases and disease-related complex traits. The identified associations made it …

Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study

Z Wei, B Yang, T Tang, Z Xiao, F Ye, X Li… - Cancer …, 2023 - Wiley Online Library
Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

TG Richardson, DJM Crouch, GM Power… - Nature …, 2022 - nature.com
The rising prevalence of childhood obesity has been postulated as an explanation for the
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …

[HTML][HTML] Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses

S Yuan, F Xu, X Li, J Chen, J Zheng, CS Mantzoros… - Cell Reports …, 2023 - cell.com
We conduct proteome-wide Mendelian randomization and colocalization analyses to
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …

Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study

D Freuer, J Linseisen, C Meisinger - BMC medicine, 2022 - Springer
Background The question of whether asthma is causally related to gastrointestinal disorders
remained unanswered so far. Thus, this study investigated whether there is such a relation …

Socioeconomic status, individual behaviors and risk for mental disorders: a Mendelian randomization study

J Cai, Z Wei, M Chen, L He, H Wang, M Li… - European …, 2022 - cambridge.org
Background There is increasing attention on the association of socioeconomic status and
individual behaviors (SES/IB) with mental health. However, the impacts of SES/IB on mental …

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time

TT Morris, J Heron, ECM Sanderson… - International Journal …, 2022 - academic.oup.com
Background Mendelian randomization (MR) is a powerful tool through which the causal
effects of modifiable exposures on outcomes can be estimated from observational data. Most …