The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …

Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for
various cerebral proteopathies. Here we leverage the unique characteristics of the …

Introduction We performed a systematic review and meta-analysis of the Alzheimer's
disease (AD) literature to examine consistency of functional connectivity alterations in AD …

As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …

Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of
synapses. Here, we present findings supporting a special role for excitatory synapses …

Abstract See Schott and Fox (doi: 10.1093/brain/awv405) for a scientific commentary on this
article. Alzheimer's disease is a multifactorial dementia disorder characterized by early …

Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest
neurodegenerative changes associated with each variant has implications for early …