Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

Articular cartilage defects are prevalent and are potentially involved in the initiation of
osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents …

The regeneration of focal articular cartilage defects is complicated by the reduced quality of
the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial …

Integrative osteochondral repair is a useful strategy for cartilage-defect repair. To mimic the
microenvironment, it is necessary that scaffolds effectively mimic the extracellular matrix of …

In orthopaedics, gene-based treatment approaches are being investigated for an array of
common-yet medically challenging-pathologic conditions of the skeletal connective tissues …

Gene therapy might represent a promising strategy for chondral and osteochondral defects
repair by balancing the management of temporary joint mechanical incompetence with …

The homeostasis of osteochondral tissue is tightly controlled by articular cartilage
chondrocytes and underlying subchondral bone osteoblasts via different internal and …

The connective tissues of the musculoskeletal system can be grouped into fibrous,
cartilaginous, and calcified tissues. While each tissue type has a distinct composition and …

Significant progress in osteochondral tissue engineering has been made for biomaterials
designed to deliver growth factors that promote tissue regeneration. However, due to …

ABSTRACT Autologous Chondrocyte Implantation (ACI) is a widely recognized method for
the repair of focal cartilage defects. Despite the accepted use, problems with this technique …