Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …

A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Repetitive transcranial magnetic stimulation (rTMS) is emerging as a non-invasive
therapeutic strategy in the battle against Alzheimer's disease. Alzheimer's disease patients …

Numerous light-based diagnostic and therapeutic devices are routinely used in the clinic.
These devices have a familiar look as items plugged in the wall or placed at patients' …

Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence
continuing to grow in part because of the aging world population. This neurodegenerative …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …