Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Sex and gender—biological and social constructs—significantly impact the prevalence of
protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta …

White matter hyperintensities (WMHs) frequently occur in Alzheimer's Disease (AD) and
have a contribution from ischemia, though their relationship with β-amyloid and …

It is well known that vascular factors and specific social determinants of health contribute to
dementia risk and that the prevalence of these risk factors differs according to race and sex …

Background Damage to the cerebral vasculature can lead to vascular contributions to
cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to …

Abstract Introduction White matter hyperintensities (WMHs) are common magnetic
resonance imaging (MRI) findings in the aging population in general, as well as in patients …

Cerebral white matter rarefaction (CWMR) was considered by Binswanger and Alzheimer to
be due to cerebral arteriolosclerosis. Renewed attention came with CT and MR brain …

Cardiometabolic risk (CMR) factors are associated with accelerated brain aging and
increased risk for sex‐dimorphic illnesses such as Alzheimer's disease (AD). Yet, it is …

Our goal was to understand the complex relationship between age, sex, midlife risk factors,
and early white matter changes measured by diffusion tensor imaging (DTI) and their role in …

Objective To evaluate potential sex-specific effects of multiple cardiovascular risk factors on
white matter pathology in normal aging men and women, as well as potential sex …