Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …

Beta-cell mass regulation represents a critical issue for understanding diabetes, a disease
characterized by a near-absolute (type 1) or relative (type 2) deficiency in the number of …

Two major initiatives are under way to correct the β-cell deficit of diabetes: one would
generate β-cells ex vivo that are suitable for transplantation, and the second would stimulate …

Aims/hypothesis Transplantation of insulin-producing beta cells from donors can cure
diabetes, but they are available in insufficient quantities. In this study, we investigated the …

It is still unclear which factors regulate pancreatic regeneration and β-cell neogenesis and
which precursor cells are involved. We evaluated the role of intravenously infused gastrin in …

The pancreas is a complex organ with exocrine and endocrine components. Many
pathologies impair exocrine function, including chronic pancreatitis, cystic fibrosis and …

Aims/hypothesis Increasing beta-cell mass and/or function could restore glucose
homeostasis in diabetes mellitus. Hitherto, trophic factors for beta-cell regeneration after …

Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …

The gastrointestinal peptide hormones gastrin and cholecystokinin (CCK) are well known for
their ability to stimulate gastric acid secretion and pancreatic enzyme secretion, respectively …

Objective Acinar cells display plasticity in vitro and in vivo and can activate a variety of
differentiation programmes that may contribute to pancreatic diseases. The aims were to …