Heparan sulphate proteoglycans fine-tune mammalian physiology
JR Bishop, M Schuksz, JD Esko - Nature, 2007 - nature.com
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied
so far and are a major component of extracellular matrices. Studies of model organisms and …
so far and are a major component of extracellular matrices. Studies of model organisms and …
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure
MJ Harris, DM Juriloff - Birth Defects Research Part A: Clinical …, 2010 - Wiley Online Library
The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …
[HTML][HTML] Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses
V De Pasquale, LM Pavone - … et Biophysica Acta (BBA)-Molecular Basis of …, 2019 - Elsevier
Heparan sulfate proteoglycans (HSPGs) are complex carbohydrate-modified proteins
ubiquitously expressed on cell surfaces, extracellular matrix and basement membrane of …
ubiquitously expressed on cell surfaces, extracellular matrix and basement membrane of …
Dynamic movement of the Golgi unit and its glycosylation enzyme zones
A Harada, M Kunii, K Kurokawa, T Sumi… - Nature …, 2024 - nature.com
Abstract Knowledge on the distribution and dynamics of glycosylation enzymes in the Golgi
is essential for better understanding this modification. Here, using a combination of …
is essential for better understanding this modification. Here, using a combination of …
Genetic and epigenetic mechanisms of gene regulation during lens development
Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …
expression, extracellular signaling and cellular differentiation during lens development …
The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
The cartilage growth plate is a specialized developmental tissue containing characteristic
zonal arrangements of chondrocytes. The proliferative and differentiative states of …
zonal arrangements of chondrocytes. The proliferative and differentiative states of …
Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans
C Kirn-Safran, MC Farach-Carson… - Cellular and Molecular Life …, 2009 - Springer
Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-
bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and …
bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and …
Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis
To examine the role of endothelial heparan sulfate during angiogenesis, we generated mice
bearing an endothelial-targeted deletion in the biosynthetic enzyme N-acetylglucosamine N …
bearing an endothelial-targeted deletion in the biosynthetic enzyme N-acetylglucosamine N …
Use of a natural hybrid zone for genomewide association mapping of craniofacial traits in the house mouse
The identification of the genes involved in morphological variation in nature is still a major
challenge. Here, we explore a new approach: we combine 178 samples from a natural …
challenge. Here, we explore a new approach: we combine 178 samples from a natural …
Endothelial heparan sulfate in angiogenesis
Heparan sulfate (HS) is a linear polysaccharide composed of 50–200 glucosamine and
uronic acid (glucuronic acid or iduronic acid) disaccharide repeats with epimerization and …
uronic acid (glucuronic acid or iduronic acid) disaccharide repeats with epimerization and …