Matrix stiffness: the conductor of organ fibrosis
Abstract Purpose of Review Organ fibrosis is a lethal component of scleroderma. The
hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by …
hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by …
New drugs for NAFLD: lessons from basic models to the clinic
KC Reimer, A Wree, C Roderburg, F Tacke - Hepatology international, 2020 - Springer
The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly
harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic …
harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic …
[HTML][HTML] Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction
G Gilles, AD McCulloch, CH Brakebusch, KM Herum - PLoS One, 2020 - journals.plos.org
Mechanical cues activate cardiac fibroblasts and induce differentiation into myofibroblasts,
which are key steps for development of cardiac fibrosis. In vitro, the high stiffness of plastic …
which are key steps for development of cardiac fibrosis. In vitro, the high stiffness of plastic …
[HTML][HTML] Exercise intervention prevents early aged hypertension-caused cardiac dysfunction through inhibition of cardiac fibrosis
Y Hong, AL Yang, JKS Wong, K Masodsai… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Background: An inappropriate accumulation of fibrillar collagen is a common pathologic
feature of early aged hypertensive heart disease, but little information regarding the effects …
feature of early aged hypertensive heart disease, but little information regarding the effects …
Cardiac fibroblasts: from origin to injury
MD Tallquist - Current opinion in physiology, 2018 - Elsevier
Highlights•Embryonic endocardium and epicardium produce ventricular cardiac
fibroblasts.•Resident cardiac fibroblasts are responsible for fibrogenesis.•Cardiac fibroblasts …
fibroblasts.•Resident cardiac fibroblasts are responsible for fibrogenesis.•Cardiac fibroblasts …
[HTML][HTML] Recent advances in single-cell profiling and multispecific therapeutics: paving the way for a new era of precision medicine targeting cardiac fibroblasts
SY Shi, X Luo, TM Yamawaki, CM Li, B Ason… - Current Cardiology …, 2021 - Springer
Abstract Purpose of Review Cardiac fibroblast activation contributes to fibrosis, maladaptive
remodeling and heart failure progression. This review summarizes the latest findings on …
remodeling and heart failure progression. This review summarizes the latest findings on …
RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism
S Banerjee, VRC Onwunyi, J Hong, S Martineau… - bioRxiv, 2024 - biorxiv.org
Background: Pulmonary hypertension (PH)-induced right ventricular (RV) failure (PH-RVF)
is a significant prognostic determinant of mortality and is characterized by RV hypertrophy …
is a significant prognostic determinant of mortality and is characterized by RV hypertrophy …