A biomolecular electrostatics solver using Python, GPUs and boundary elements that can handle solvent-filled cavities and Stern layers

CD Cooper, JP Bardhan, LA Barba - Computer physics communications, 2014 - Elsevier
The continuum theory applied to biomolecular electrostatics leads to an implicit-solvent
model governed by the Poisson–Boltzmann equation. Solvers relying on a boundary …

Solvation thermodynamics of solutes in water and ionic liquids using the multiscale solvation-layer interface condition continuum model

AM Rahimi, S Jamali, JP Bardhan… - Journal of Chemical …, 2022 - ACS Publications
Molecular assembly processes are generally driven by thermodynamic properties in
solutions. Atomistic modeling can be very helpful in designing and understanding complex …

Probing protein orientation near charged nanosurfaces for simulation-assisted biosensor design

CD Cooper, NC Clementi, LA Barba - The Journal of Chemical Physics, 2015 - pubs.aip.org
Protein-surface interactions are ubiquitous in biological processes and bioengineering, yet
are not fully understood. In biosensors, a key factor determining the sensitivity and thus the …

Poisson–Boltzmann model for protein–surface electrostatic interactions and grid-convergence study using the PyGBe code

CD Cooper, LA Barba - Computer Physics Communications, 2016 - Elsevier
Interactions between surfaces and proteins occur in many vital processes and are crucial in
biotechnology: the ability to control specific interactions is essential in fields like …

A boundary‐integral approach for the poisson–boltzmann equation with polarizable force fields

CD Cooper - Journal of Computational Chemistry, 2019 - Wiley Online Library
Implicit‐solvent models are widely used to study the electrostatics in dissolved
biomolecules, which are parameterized using force fields. Standard force fields treat the …

Computational nanoplasmonics in the quasistatic limit for biosensing applications

NC Clementi, CD Cooper, LA Barba - Physical Review E, 2019 - APS
The phenomenon of localized surface plasmon resonance (LSPR) provides high sensitivity
in detecting biomolecules through shifts in resonance frequency when a target is present …

Stochastic Scaling in Loss Functions for Physics-Informed Neural Networks

E Mills, A Pozdnyakov - arXiv preprint arXiv:2208.03776, 2022 - arxiv.org
Differential equations are used in a wide variety of disciplines, describing the complex
behavior of the physical world. Analytic solutions to these equations are often difficult to …

Biomolecular electrostatics with continuum models: A boundary integral implementation and applications to biosensors

CC Villagran - 2015 - search.proquest.com
The implicit-solvent model uses continuum electrostatic theory to represent the salt solution
around dissolved biomolecules, leading to a coupled system of the Poisson-Boltzmann and …

Biomolecular electrostatics with continuum models: a boundary integral implementation and applications to biosensors

CD Cooper Villagran - 2015 - open.bu.edu
The implicit-solvent model uses continuum electrostatic theory to represent the salt solution
around dissolved biomolecules, leading to a coupled system of the Poisson-Boltzmann and …

[引用][C] Computational nanoplasmonics for biosensing applications using PyGBe-LSPR