Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules
and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …

The preparation of pharmaceutical co-crystals using supercritical CO2 (scCO2) is reviewed.
Co-crystallization is an emerging and powerful technique to improve the physicochemical …

Over the last years, resveratrol (RES), a phytoalexin found in grape skin, has received more
attention due to its properties antioxidant, anticancer, anti-inflammatory, antimicrobial and …

The last decade has witnessed extensive growth in the field of co-crystallization for
mitigating the solubility and dissolution-related issues of poorly soluble drugs. This is largely …

Pharmaceuticals in Biopharmaceutics Classification System (BCS) Class II (low solubility,
high permeability) are often modified to improve kinetic solubility. Co-crystallization and …

The low aqueous solubility and subsequently slow dissolution rate, as well as the poor
bioavailability of several active pharmaceutical ingredients (APIs), are major challenges in …

Abstract Co-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and
pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent …