Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Defined genetic models based on human pluripotent stem cells have opened new avenues
for understanding disease mechanisms and drug screening. Many of these models assume …

Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

Creating vascular networks in tissues is crucial for tissue engineering. Although recent
studies have demonstrated the formation of vessel-like structures in a tissue model, long …

The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …

The integrity of the endothelial barrier between circulating blood and tissue is important for
blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

Formation of capillary blood vasculature is a critical requirement for native as well as
engineered organs and can be induced in vitro by coculturing endothelial cells with …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …

Convective transport can significantly distort spatial concentration gradients. Interstitial flow
is ubiquitous throughout living tissue, but our understanding of how interstitial flow affects …