Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure (HF)
cases, making it the most common type of HF, and its prevalence continues to increase in …

Cell death constitutes a critical component of the pathophysiology of cardiovascular
diseases. A growing array of non-apoptotic forms of regulated cell death (RCD)—such as …

Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients,
characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate …

Metabolic compromise is crucial in aggravating age-associated chronic inflammation,
oxidative stress, mitochondrial damage, increased LDL and triglycerides, and elevated …

In Canada and worldwide, the elderly population (ie, individuals> 65 years of age) is
increasing disproportionately relative to the total population. This is expected to have a …

Background Runt-related transcription factor-1 (RUNX1), a key member of the core-binding
factor family of transcription factors, has emerged as a novel therapeutic target for …

It has remained unclear how aging of endothelial cells (EC) contributes to pathophysiology
of individual organs. Cell senescence results in part from inactivation of telomerase (TERT) …

The complex mechanisms underlying the development of cardiovascular diseases remain
not fully elucidated. Epigenetics, which modulates gene expression without DNA sequence …

Cardiovascular diseases are a leading cause of mortality worldwide, and the risks of both
developing a disease and receiving a poor prognosis increase with age. With increasing life …

Cardiometabolic diseases (CMDs) are interrelated and multifactorial conditions, including
arterial hypertension, type 2 diabetes, heart failure, coronary artery disease, and stroke. Due …