Skeletal muscle wasting occurs in a variety of diseases including diabetes, cancer, Crohn's
disease, chronic obstructive pulmonary disease (COPD), disuse, and denervation. Tumor …

Abstract p38 MAPKs play a central role in orchestrating the cellular response to stress and
inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have …

Background: In the heart, acute injury induces a fibrotic healing response that generates
collagen-rich scarring that is at first protective but if inappropriately sustained can worsen …

Skeletal muscle can repair and regenerate due to resident stem cells known as satellite
cells. The muscular dystrophies are progressive muscle wasting diseases underscored by …

Collagen production in the adult heart is thought to be regulated by the fibroblast, although
cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular …

Skeletal muscle atrophy proceeds through a complex molecular signaling network that is
just beginning to be understood. Here, we discuss examples of recently identified molecular …

Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …

Cell communication is needed for organ function and stress responses, especially in the
heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the …

MAPK signaling consists of an array of successively acting kinases. ERK1 and-2 (ERK1/2)
are major components of the greater MAPK cascade that transduce growth factor signaling …

The muscle stem cells niche is essential in neuromuscular disorders. Muscle injury and
myofiber death are the main triggers of muscle regeneration via satellite cell activation …