Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Food intake is a complex behavior that can occur or cease to occur for a multitude of
reasons. Decisions about where, when, what, and how much to eat are not merely reflexive …

Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …

Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that
integrate energy demand as well as the reinforcing and rewarding aspects of food …

This paper reviews evidence demonstrating a bidirectional relationship between memory
and eating in humans and rodents. In humans, amnesia is associated with impaired …

Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …

Understanding the neurobiological controls of feeding behavior is critical in light of the
growing obesity pandemic, a phenomenon largely based on excessive caloric consumption …

Objective Excess nutrient supply and rapid weight gain during early life are risk factors for
the development of obesity during adulthood. This metabolic malprogramming may be …

Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …

Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone
secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological …