An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure
MJ Harris, DM Juriloff - Birth Defects Research Part A: Clinical …, 2010 - Wiley Online Library
The number of mouse mutants and strains with neural tube defects (NTDs) now exceeds
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …
240, including 205 representing specific genes, 30 for unidentified genes, and 9 …
Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …
Arylamine N-acetyltransferases: from structure to function
Arylamine N-acetyltransferases (NATs) are cytosolic conjugating enzymes which transfer an
acetyl group from acetylCoenzyme A to a xenobiotic acceptor substrate. The enzyme has an …
acetyl group from acetylCoenzyme A to a xenobiotic acceptor substrate. The enzyme has an …
Arylamine N-acetyltransferases: structural and functional implications of polymorphisms
Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines,
arylhydroxylamines and arylhydrazines with the acetyl group being transferred from …
arylhydroxylamines and arylhydrazines with the acetyl group being transferred from …
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N …
AJ Russell, IM Westwood, MHJ Crawford… - Bioorganic & medicinal …, 2009 - Elsevier
The identification, synthesis and evaluation of a series of rhodanine and thiazolidin-2, 4-
dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and …
dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and …
Arylamine N-acetyltransferases–from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention
E Sim, G Fakis, N Laurieri, S Boukouvala - Advances in pharmacology, 2012 - Elsevier
Arylamine N-acetyltransferases (NATs) are defined as xenobiotic metabolizing enzymes,
adding an acetyl group from acetyl coenzyme A (CoA) to arylamines and arylhydrazines …
adding an acetyl group from acetyl coenzyme A (CoA) to arylamines and arylhydrazines …
[HTML][HTML] Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases
MW Stepp, G Mamaliga, MA Doll, JC States… - … and biophysics reports, 2015 - Elsevier
Arylamine N-acetyltransferases (NATs) are drug and xenobiotic metabolizing enzymes that
catalyze the N-acetylation of arylamines and hydrazines and the O-acetylation of N-hydroxy …
catalyze the N-acetylation of arylamines and hydrazines and the O-acetylation of N-hydroxy …
[HTML][HTML] Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism
L Wakefield, V Cornish, H Long, WJ Griffiths… - … and biophysical research …, 2007 - Elsevier
The mouse arylamine N-acetyltransferase 2 (Nat2) and its homologue (NAT1) in humans
are known to detoxify xenobiotic arylamines and are also thought to play a role in …
are known to detoxify xenobiotic arylamines and are also thought to play a role in …
The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the “gold standard” revisited
F Guedj, E Kane, LA Bishop, JLA Pennings, Y Herault… - bioRxiv, 2022 - biorxiv.org
Despite many successful preclinical treatment studies to improve neurocognition in the
Ts65Dn mouse model of Down syndrome (DS), translation to humans has failed. This raises …
Ts65Dn mouse model of Down syndrome (DS), translation to humans has failed. This raises …
[HTML][HTML] Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1
A Kawamura, I Westwood, L Wakefield, H Long… - Biochemical …, 2008 - Elsevier
There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC
2.3. 1.5), although first identified as a homologue of a drug-metabolising enzyme, appears to …
2.3. 1.5), although first identified as a homologue of a drug-metabolising enzyme, appears to …