Epidermal growth factor receptor (EGFR) signaling in cancer
N Normanno, A De Luca, C Bianco, L Strizzi… - Gene, 2006 - Elsevier
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …
EGF–ERBB signalling: towards the systems level
A Citri, Y Yarden - Nature reviews Molecular cell biology, 2006 - nature.com
Signalling through the ERBB/HER receptors is intricately involved in human cancer and
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5+) stem cells
reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply …
reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply …
The epidermal growth factor receptor family: biology driving targeted therapeutics
MJ Wieduwilt, MM Moasser - Cellular and molecular life sciences, 2008 - Springer
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …
EGF receptor ligands
RC Harris, E Chung, RJ Coffey - The EGF Receptor Family, 2003 - Elsevier
Publisher Summary This chapter focuses on epidermal growth factor (EGF) receptor ligands.
The mammalian ligands that bind the EGF receptor (EGFR [HER1, Erb-B1]) include EGF …
The mammalian ligands that bind the EGF receptor (EGFR [HER1, Erb-B1]) include EGF …
[HTML][HTML] EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila
H Jiang, MO Grenley, MJ Bravo, RZ Blumhagen… - Cell stem cell, 2011 - cell.com
Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or
aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis …
aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis …
Identification of a cKit+ colonic crypt base secretory cell that supports Lgr5+ stem cells in mice
BACKGROUND & AIMS: Paneth cells contribute to the small intestinal niche of Lgr5+ stem
cells. Although the colon also contains Lgr5+ stem cells, it does not contain Paneth cells. We …
cells. Although the colon also contains Lgr5+ stem cells, it does not contain Paneth cells. We …
Epidermal growth factor, from gene organization to bedside
F Zeng, RC Harris - Seminars in cell & developmental biology, 2014 - Elsevier
In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying
nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a …
nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a …
[HTML][HTML] Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism
F Yan, H Cao, TL Cover… - The Journal of …, 2011 - Am Soc Clin Investig
Preclinical studies with probiotics continue to unravel mechanisms of cytoprotection and
suggest that approaches utilizing microbial products as therapeutics in acute and chronic …
suggest that approaches utilizing microbial products as therapeutics in acute and chronic …
EGFR family: Structure physiology signalling and therapeutic targets†
AW Burgess - Growth factors, 2008 - Taylor & Francis
There are four members of the EGFR family: EGFR, erbB2, erbB3 and erbB4. These
receptors form ligand-activated oligomers which regulate intracellular processes via an …
receptors form ligand-activated oligomers which regulate intracellular processes via an …