Abstract Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much
attention because of its incredible roles in tissue differentiation, regeneration, and neural …

The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients.
The mechanisms of doxorubicin-induced cardiotoxicity remain incompletely understood …

Cell death, as a final cellular decision which is reached following complex communications,
represents a critical process with which to maintain organismic homeostasis. Different …

Injury to the heart results in cardiomyocyte cell death and can lead to pathological
remodeling of remaining cells, contributing to heart failure. Despite the therapeutic potential …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

Patient deaths resulting from cardiovascular diseases are increasing across the globe,
posing the greatest risk to patients in developed countries. Myocardial infarction, as a result …