Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
Current status of pluripotent stem cells: moving the first therapies to the clinic
EA Kimbrel, R Lanza - Nature reviews Drug discovery, 2015 - nature.com
Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative
medicine owing to their ability to differentiate into any cell type in the body. After more than …
medicine owing to their ability to differentiate into any cell type in the body. After more than …
Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value
JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …
[HTML][HTML] Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients
CJ Rogers, RJ Harman, BA Bunnell… - Journal of translational …, 2020 - Springer
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei
province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per …
province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per …
Exosomes generated from iPSC-derivatives: new direction for stem cell therapy in human heart diseases
Cardiovascular disease (CVD) is the leading cause of death in modern society. The adult
heart innately lacks the capacity to repair and regenerate the damaged myocardium from …
heart innately lacks the capacity to repair and regenerate the damaged myocardium from …
[HTML][HTML] Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives
E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …
significant attention in the regenerative medicine due to the ability of these cells to proliferate …
Hepatocyte growth factor is required for mesenchymal stromal cell protection against bleomycin-induced pulmonary fibrosis
EF Cahill, H Kennelly, F Carty… - Stem cells …, 2016 - academic.oup.com
The incidence of idiopathic pulmonary fibrosis is on the rise and existing treatments have
failed to halt or reverse disease progression. Mesenchymal stromal cells (MSCs) have …
failed to halt or reverse disease progression. Mesenchymal stromal cells (MSCs) have …
[HTML][HTML] Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Abstract Background The Wnt signaling pathway has been implicated in the pathogenesis of
fibrotic disorders and malignancies. Hence, we aimed to assess the potential of the induced …
fibrotic disorders and malignancies. Hence, we aimed to assess the potential of the induced …
[HTML][HTML] Enhancing cutaneous wound healing based on human induced neural stem cell-derived exosomes
J Li, H Gao, Y Xiong, L Wang, H Zhang… - International Journal …, 2022 - ncbi.nlm.nih.gov
Background Wound healing of skin is a complicated process. Cutaneous innervation and
neurotrophic factors could participate in multiple stages of wound healing. Neurotrophic …
neurotrophic factors could participate in multiple stages of wound healing. Neurotrophic …
[HTML][HTML] The hepatocyte growth factor-expressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo
S Hu, J Li, X Xu, A Liu, H He, J Xu, Q Chen… - Stem cell research & …, 2016 - Springer
Background Acute respiratory distress syndrome (ARDS) is a life-threatening condition in
critically ill patients. Recently, we have found that mesenchymal stem cells (MSC) improved …
critically ill patients. Recently, we have found that mesenchymal stem cells (MSC) improved …