Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the
exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been …

Abstract Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in
breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Background: Cerebrospinal fluid (CSF) biomarkers have been suggested to predict multiple
sclerosis (MS) after clinically isolated syndromes, but studies investigating long-term …

There is a strong unmet clinical need for objective body fluid biomarkers to assist early
diagnosis and estimate long-term prognosis, monitor treatment response and predict …

Inflammation plays a vital role at different stages of tumor progression. The development of
tumors is affected by inflammatory mediators produced by the tumor and the host. YKL …

The tumor microenvironment contributes to cancer progression, in part through interactions
between tumor and normal stromal cells. This study analyzed morphological and molecular …

Abstract The interleukin-13 receptor alpha2 (IL-13Rα2) is a cancer-associated receptor
overexpressed in human glioblastoma multiforme (GBM). This receptor is undetectable in …

Background Murine breast cancer models relying on intraductal tumor cell inoculations are
attractive because they allow the study of breast cancer from early ductal carcinoma in situ to …