Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Carcinogenesis: Failure of resolution of inflammation?

A Fishbein, BD Hammock, CN Serhan… - Pharmacology & …, 2021 - Elsevier
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Soluble epoxide hydrolase: a potential target for metabolic diseases: 可溶性表氧化物酶: 代谢性疾病的潜在治疗靶点

J He, C Wang, Y Zhu, D Ai - Journal of diabetes, 2016 - Wiley Online Library
摘要环氧‐二十碳三烯酸(Epoxyeicosatrienoic acids, EET) 是花生四烯酸的重要代谢产物. EET
在包括动脉粥样硬化, 高血压, 心脏纤维化, 糖尿病, 非酒精性脂肪肝以及肾脏疾病在内的诸多 …

Targeting autophagy in obesity: from pathophysiology to management

Y Zhang, JR Sowers, J Ren - Nature Reviews Endocrinology, 2018 - nature.com
Obesity poses a severe threat to human health, including the increased prevalence of
hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and …

[HTML][HTML] Eicosanoids: the overlooked storm in coronavirus disease 2019 (COVID-19)?

BD Hammock, W Wang, MM Gilligan… - The American journal of …, 2020 - Elsevier
Severe coronavirus disease 2019 (COVID-19) symptoms, including systemic inflammatory
response and multisystem organ failure, are now affecting thousands of infected patients …

Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies

K Hildreth, SD Kodani, BD Hammock, L Zhao - The Journal of nutritional …, 2020 - Elsevier
Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet.
Cytochrome P450-derived LA metabolites 9, 10-epoxyoctadecenoic acid (9, 10-EpOME), 12 …

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

T Ishihara, M Yoshida, M Arita - International immunology, 2019 - academic.oup.com
Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid,
docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial …

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

L Martínez-Fernández, LM Laiglesia, AE Huerta… - Prostaglandins & other …, 2015 - Elsevier
The n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic
(EPA) and docosahexaenoic (DHA) have been reported to improve obesity-associated …