Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2,
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …
Rational selection of syngeneic preclinical tumor models for immunotherapeutic drug discovery
SIS Mosely, JE Prime, RCA Sainson… - Cancer immunology …, 2017 - AACR
Murine syngeneic tumor models are critical to novel immuno-based therapy development,
but the molecular and immunologic features of these models are still not clearly defined. The …
but the molecular and immunologic features of these models are still not clearly defined. The …
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
R Jiang, J Tang, Y Chen, L Deng, J Ji, Y Xie… - Nature …, 2017 - nature.com
Long noncoding RNAs play a pivotal role in T-helper cell development but little is known
about their roles in Treg differentiation and functions during the progression of …
about their roles in Treg differentiation and functions during the progression of …
Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development
CR Figueiredo, H Kalirai, JJ Sacco… - The Journal of …, 2020 - Wiley Online Library
Immunotherapy using immune checkpoint inhibitors (ICIs) induces durable responses in
many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver …
many metastatic cancers. Metastatic uveal melanoma (mUM), typically occurring in the liver …
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
HK Park, NG Yoon, JE Lee, S Hu, S Yoon… - … & molecular medicine, 2020 - nature.com
Abstract The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell
cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in …
cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in …
Assessing potential mechanisms of arsenic-induced skin lesions and cancers: human and in vitro evidence
Q Zeng, A Zhang - Environmental Pollution, 2020 - Elsevier
Environmental exposure to arsenic is a major public health challenge worldwide. In detailing
the hallmark signs of chronic arsenic exposure, previous studies have shown that epigenetic …
the hallmark signs of chronic arsenic exposure, previous studies have shown that epigenetic …
Transcriptome analysis of the regenerating tail vs. the scarring limb in lizard reveals pathways leading to successful vs. unsuccessful organ regeneration in amniotes
Background: Lizards are amniotes regenerating the tail but not the limb, and no information
on their different gene expression is available. Results: Transcriptomes of regenerating tail …
on their different gene expression is available. Results: Transcriptomes of regenerating tail …
[HTML][HTML] TRPV6 as a target for cancer therapy
JM Stewart - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Two decades ago a class of ion channels, hitherto unsuspected, was discovered. In
mammals these Transient Receptor Potential channels (TRPs) have not only expanded in …
mammals these Transient Receptor Potential channels (TRPs) have not only expanded in …
The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
Z Zhou, J Song, W Li, X Liu, L Cao, L Wan… - Journal of Experimental …, 2017 - Springer
Background The tumor acidic microenvironment, a common biochemical event in solid
tumors, offers evolutional advantage for tumors cells and even enhances their aggressive …
tumors, offers evolutional advantage for tumors cells and even enhances their aggressive …